Deletion of CD2-like gene from the genome of African swine fever virus strain Georgia does not attenuate virulence in swine.

ABSTRACT: The CD2-like African swine fever virus (ASFV) gene 8DR, (also known as EP402R) encodes for a structural transmembrane glycoprotein that has been shown to mediate hemadsorption and be involved in host immunomodulation as well as the induction of protective immune response. In addition, several natural ASFV isolates showing decreased virulence in swine has been shown to be non-hemadsorbing suggesting an association between altered or deleted forms of 8DR and virus attenuation. Here we demonstrate that deletion of 8DR gene from the genome of ASFV Georgia2010 isolate (ASFV-G-Δ8DR) does not significantly alter the virulence of the virus. ASFV-G-Δ8DR inoculated intramuscularly or intranasally (in a range of 10² to 10⁴ TCID₅₀) produced a clinical disease in domest

SUBMITTER: Borca MV 

PROVIDER: S-EPMC6965178 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature