Identification of Distinct Immune Subtypes in Colorectal Cancer Based on the Stromal Compartment.

ABSTRACT: The tumor environment is of vital importance for the incidence and development of colorectal cancer. Increasing evidence in recent years has elaborated the vital role of the tumor environment in cancer subtype classification and patient prognosis, but a comprehensive understanding of the colorectal tumor environment that is purely dependent on the stromal compartment is lacking. To decipher the tumor environment in colorectal cancer and explore the role of its immune context in cancer classification, we performed a gene expression microarray on the stromal compartment of colorectal cancer and adjacent normal tissues. Through the integrated analysis of our data with public gene expression microarray data of stromal and epithelial colorectal cancer tissues processed through laser capture mic

SUBMITTER: Shen R 

PROVIDER: S-EPMC6965328 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature