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Complete Genome Sequence of Klebsiella pneumoniae Strain TK421, a Conjugative Hypervirulent Isolate.

ABSTRACT: Klebsiella pneumoniae is a Gram-negative bacterium that is a major cause of nosocomial infections worldwide. Here, we present the complete genome sequence of TK421, a clinical bacteremia isolate containing a hypervirulence plasmid carrying tra-associated conjugation machinery genes. Emergence of conjugative hypervirulence plasmids could portend rapid dissemination of hypervirulence among multidrug-resistant K. pneumoniae strains.

SUBMITTER: Kochan TJ 

PROVIDER: S-EPMC6965585 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Complete Genome Sequence of Klebsiella pneumoniae Strain TK421, a Conjugative Hypervirulent Isolate.

Kochan Travis J TJ   Ozer Egon A EA   Pincus Nathan B NB   Fitzpatrick Margaret A MA   Hauser Alan R AR  

Microbiology resource announcements 20200116 3

<i>Klebsiella pneumoniae</i> is a Gram-negative bacterium that is a major cause of nosocomial infections worldwide. Here, we present the complete genome sequence of TK421, a clinical bacteremia isolate containing a hypervirulence plasmid carrying <i>tra</i>-associated conjugation machinery genes. Emergence of conjugative hypervirulence plasmids could portend rapid dissemination of hypervirulence among multidrug-resistant <i>K. pneumoniae</i> strains. ...[more]

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