Δ⁸ -Tetrahydrocannabivarin has potent anti-nicotine effects in several rodent models of nicotine dependence.

ABSTRACT:

Background and purpose

Both types of cannabinoid receptors-CB₁ and CB₂ -regulate brain functions relating to addictive drug-induced reward and relapse. CB₁ receptor antagonists and CB₂ receptor agonists have anti-addiction efficacy, in animal models, against a broad range of addictive drugs. Δ⁹ -Tetrahydrocannabivarin (Δ⁹ -THCV)-a cannabis constituent-acts as a CB₁ antagonist and a CB₂ agonist. Δ⁸ -Tetrahydrocannabivarin (Δ⁸ -THCV) is a Δ⁹ -THCV analogue with similar combined CB₁ antagonist/CB₂ agonist properties.

Experimental approach

We tested Δ⁸ -THCV in seven different rodent models relevant to nicotine dependence-nicot

SUBMITTER: Xi ZX 

PROVIDER: S-EPMC6965695 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature