CHI3L1 is correlated with childhood asthma.

ABSTRACT: OBJECTIVE:The aim of this study was to assess the association between CHI3L1 gene two single nucleotide polymorphisms (SNPs) (rs12141494 and rs4950928) and susceptibility to pediatric asthma in a Chinese Han population. METHODS:The case-control study was carried out on 115 children with asthma and 108 healthy controls. Genotypes of rs12141494 and rs4950928 within CHI3L1 gene were determined with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) approach. Chi-square test was employed to analyze the differences of genotype and allele frequencies of the two polymorphisms between case and control groups. Odds ratios (ORs) and 95% confidence intervals (CIs) were applied to explain relative susceptibility of pediatric asthma. RESULTS:The frequencies of genotypes and a

SUBMITTER: Chen F 

PROVIDER: S-EPMC6965777 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature