MicroRNAs and regulated interaction networks reveal differences between adult and pediatric acute myeloid leukemia.

ABSTRACT: OBJECTIVES:The purpose of this study was to identify featured microRNAs and their regulated network between adult and pediatric acute myeloid leukemia (AML) and find potential utility as biomarkers for diagnosis and treatment of pediatric AML. METHODS:We downloaded the microRNA expression dataset GSE35320 from Gene Expression Omnibus database and selected expression chips from bone marrow of 71 pediatric AML samples and 6 adulthood AML samples. Differentially expressed microRNAs were identified by Wilcox test. The target genes of these microRNAs were predicted using an integrative method and their functional enrichment analysis was performed using DAVID. Finally, STRING database and Cytoscape software was used to construct and analyze the interaction network. RESULTS:A total of 7 different

SUBMITTER: Liu J 

PROVIDER: S-EPMC6965806 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature