GSTP1 exon 5 rs200139798 polymorphism and clinicopathological characteristics of gastric cancer in Chinese patients.

ABSTRACT: This study was undertaken to detect the incidence of variations in exon 5 of GSTP1, a member of the glutathione-S-transferase family, in gastric cancer in relation to histological parameters. The study included 216 gastric cancers and 300 benign gastric diseases as controls. DNA was extracted from paraffin-embedded tissues and polymerase chain reaction-restriction fragment length polymorphism analysis was performed to examine the GSTP1 Ile105Val gene polymorphism in the study participants. A positive association between GSTP1 polymorphism and gastric cancer was observed in subjects carrying at least one G allele (AG and GG); the adjusted odds ratio (OR) for GSTP1 AA versus AG+GG was 1.416 (95% confidence interval [CI] 1.007 to 1.989, after controlling for age and gender). Patients over 50

SUBMITTER: Wang X 

PROVIDER: S-EPMC6965944 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature