Association between ACE gene polymorphisms and Alzheimer's disease in Han population in Hebei Peninsula.

ABSTRACT: PURPOSE:This study aimed to detect the association between angiotensin I converting enzyme (ACE) gene polymorphisms (rs4343 and rs1800764) and Alzheimer's disease (AD) in Han population in Hebei Peninsular. METHODS:We recruited 113 AD patients and 142 healthy individuals in this case-control study. Differences of genotypes, alleles and haplotypes in two groups were analyzed by chi-square test. Besides, odds ratios (ORs) and 95% confidence intervals (CIs) were used to represent the relative risk of AD. At last, the analyses of linkage disequilibrium and haplotypes were done with HaploView software. RESULTS:In the analyses of genotypes and alleles of ACE polymorphisms (rs4343 and rs1800764) in AD, no obvious association was found between genotypes and alleles of rs4343 with the susceptibilit

SUBMITTER: Wang X 

PROVIDER: S-EPMC6965948 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature