Effect of interactions between LEPR polymorphisms and smoking on coronary artery disease susceptibility.

ABSTRACT: OBJECTIVE:This study was designed with the purpose of analyzing the relationship between the interactions of leptin receptor (LEPR) rs1137101, rs1137100 polymorphisms with smoking and the susceptibility to coronary artery disease (CAD). METHODS:The subjects of this study consisted of 101 CAD patients and 110 healthy people frequency-matched with the former in age and sex. The genotyping of LEPR polymorphisms were performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The distribution differences of genotype and allele between two groups was estimated by χ2 test. The relative risk of CAD was showed by odds ratio (OR) with 95% confidence interval (95% CI). Crossover analysis was applied in the studying of gene-environment interactions. RESULTS:LEPR

SUBMITTER: Shi R 

PROVIDER: S-EPMC6966009 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature