MMP-2 and MMP-9 gene polymorphisms associated with cervical cancer risk.

ABSTRACT: AIM:To inquire into whether there is any relationship between MMP-2 rs2285053 and MMP-9 rs3918242 polymorphisms and the onset risk of cervical cancer (CC) and invasion and metastasis. METHODS:Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was utilized to examine the frequency and distribution of MMP-2 rs2285053 and MMP-9 rs3918242 polymorphisms in 150 CC patients and 120 healthy individuals who were matched therewith in age and gender, and the CC risk and invasion and metastasis condition of individuals carrying different genotypes of the two single nucleotide polymorphisms (SNPs) were compared. The data were processed by SPSS 18.0 software. RESULTS:The differences of genotype distribution frequencies of the two SNPs between the two groups were not app

SUBMITTER: Zhang H 

PROVIDER: S-EPMC6966040 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature