Association between PEDF gene polymorphisms and the risk of age-related macular degeneration.

ABSTRACT: OBJECTIVE:Pigment epithelium-derived factor (PEDF) strongly inhibits angiogenesis, and plays an important role in retinoblastoma cells. In this study we detect the association of PEDF gene polymorphisms (rs1136287 and rs12150053) and age-related macular degeneration (AMD) risk. METHODS:This is a case-control study including 118 AMD patients and 121 healthy controls. PEDF gene polymorphisms were genotyped by TaqMan method. Hardy-Weinberg equilibrium (HWE) was used to detect the representativeness of the cases and controls. Differences of genotype and allele distributions of PEDF polymorphisms were calculated by Chi-square test. Odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs) were used to present the relative risk of AMD. RESULTS:Genotype and allele distributions in co

SUBMITTER: Li Y 

PROVIDER: S-EPMC6966057 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature