Heterogeneity of penicillin-non-susceptible group B streptococci isolated from a single patient in Germany.

ABSTRACT:

Objectives

Streptococcus agalactiae [group B streptococci (GBS)] have been considered uniformly susceptible to penicillin. However, increasing reports from Asia and North America are documenting penicillin-non-susceptible GBS (PRGBS) with mutations in pbp genes. Here we report, to the best of our knowledge, the first two PRGBS isolates recovered in Europe (AC-13238-1 and AC-13238-2), isolated from the same patient.

Methods

Two different colony morphologies of GBS were noted from a surgical abscess drainage sample. Both were serotyped and antimicrobial susceptibility testing was performed by different methodologies. High-throughput sequencing was done to compare the isolates at the genomic level, to identify their capsular type and ST, to evaluate mutations in the pbp genes a

SUBMITTER: van der Linden M 

PROVIDER: S-EPMC6966095 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature