Blood-Brain Barrier and Delivery of Protein and Gene Therapeutics to Brain.

ABSTRACT: Alzheimer's disease (AD) and treatment of the brain in aging require the development of new biologic drugs, such as recombinant proteins or gene therapies. Biologics are large molecule therapeutics that do not cross the blood-brain barrier (BBB). BBB drug delivery is the limiting factor in the future development of new therapeutics for the brain. The delivery of recombinant protein or gene medicines to the brain is a binary process: either the brain drug developer re-engineers the biologic with BBB drug delivery technology, or goes forward with brain drug development in the absence of a BBB delivery platform. The presence of BBB delivery technology allows for engineering the therapeutic to enable entry into the brain across the BBB from blood. Brain drug development may still take place in

SUBMITTER: Pardridge WM 

PROVIDER: S-EPMC6966240 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature