Hypoactivity in the Paraterminal Gyrus Following Bilateral Anterior Capsulotomy.

ABSTRACT:

Objective

Bilateral anterior capsulotomy (BAC) is one of the ablative neurosurgical procedures used to treat major depressive disorder or obsessive-compulsive disorder when all other therapies fail. Tristolysis, a reduction in sadness, is the most striking clinical effect of BAC and is seen in the first 1 to 2 weeks after surgery. This retrospective study measured regional cerebral blood flow (rCBF) following surgery to identify which cortical regions were impacted and could account for this clinical effect.

Methods

All patients had their capsulotomies done in Vancouver by the same team. Pre- and postoperative single-photon emission computed tomography perfusion scans were analyzed for 10 patients with major depressive disorder and 3 with obsessive-compulsive disorder. rCBF

SUBMITTER: Hurwitz TA 

PROVIDER: S-EPMC6966241 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature