Cancer Is Associated with Alterations in the Three-Dimensional Organization of the Genome.

ABSTRACT: The human genome is organized into topologically associating domains (TADs), which represent contiguous regions with a higher frequency of intra-interactions as opposed to inter-interactions. TADs contribute to gene expression regulation by restricting the interactions between their regulatory elements, and TAD disruption has been associated with cancer. Here, we provide a proof of principle that mutations within TADs can be used to predict the survival of cancer patients. Specifically, we constructed a set of 1467 consensus TADs representing the three-dimensional organization of the human genome and used Cox regression analysis to identify a total of 35 prognostic TADs in different cancer types. Interestingly, only 46% of the 35 prognostic TADs comprised genes with known clinical relevanc

SUBMITTER: Li L 

PROVIDER: S-EPMC6966451 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature