Immunotherapy in Pediatric Solid Tumors-A Systematic Review.

ABSTRACT: Despite advances in the treatment of many pediatric solid tumors, children with aggressive and high-risk disease continue to have a dismal prognosis. For those presenting with metastatic or recurrent disease, multiple rounds of intensified chemotherapy and radiation are the typical course of action, but more often than not, this fails to control the progression of the disease. Thus, new therapeutics are desperately needed to improve the outcomes for these children. Recent advances in our understanding of both the immune system's biology and its interaction with tumors have led to the development of novel immunotherapeutics as alternative treatment options for these aggressive malignancies. Immunotherapeutic approaches have shown promising results for pediatric solid tumors in early clinica

SUBMITTER: Marayati R 

PROVIDER: S-EPMC6966467 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature