An Effective Multi-Stage Liposomal DNA Origami Nanosystem for In Vivo Cancer Therapy.

ABSTRACT: DNA origami systems could be important candidates for clinical applications. Unfortunately, their intrinsic properties such as the activation of non-specific immune system responses leading to inflammation, instability in physiological solutions, and a short in vivo lifetime are the major challenges for real world applications. A compact short tube DNA origami (STDO) of 30 nm in length and 10 nm in width was designed to fit inside the core of a stealth liposome (LSTDO) of about 150 nm to remote load doxorubicin. Biocompatibility was tested in three-dimensional (3D) organoid cultures and in vivo. Efficacy was evaluated in different cell lines and in a xenograft breast cancer mouse model. As described in a previous work, LSTDO is highly stable and biocompatible, escaping the recognition of t

SUBMITTER: Palazzolo S 

PROVIDER: S-EPMC6966502 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature