Tumor Suppressor Function of miR-127-3p and miR-376a-3p in Osteosarcoma Cells.

ABSTRACT: Since the introduction of high-dose chemotherapy about 35 years ago, survival rates of osteosarcoma patients have not been significantly improved. New therapeutic strategies replacing or complementing conventional chemotherapy are therefore urgently required. MicroRNAs represent promising targets for such new therapies, as they are involved in the pathology of multiple types of cancer, and aberrant expression of several miRNAs has already been shown in osteosarcoma. In this study, we identified silencing of miR-127-3p and miR-376a-3p in osteosarcoma cell lines and tissues and investigated their role as potential tumor suppressors in vitro and in vivo. Transfection of osteosarcoma cells (n = 6) with miR-127-3p and miR-376a-3p mimics significantly inhibited proliferation and reduced the colo

SUBMITTER: Fellenberg J 

PROVIDER: S-EPMC6966509 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature