Deterioration in Muscle Mass and Physical Function Differs According to Weight Loss History in Cancer Cachexia.

ABSTRACT: Muscle mass and physical function (PF) are common co-primary endpoints in cancer cachexia trials, but there is a lack of data on how these outcomes interact over time. The aim of this secondary analysis of data from a trial investigating multimodal intervention for cancer cachexia (ClinicalTrials.gov: NCT01419145) is to explore whether changes in muscle mass and PF are associated with weight loss and cachexia status at baseline. Secondary analysis was conducted using data from a phase II randomized controlled trial including 46 patients with stage III-IV non-small cell lung cancer (n = 26) or inoperable pancreatic cancer (n = 20) due to commence chemotherapy. Cachexia status at baseline was classified according to international consensus. Muscle mass (assessed using computed tomography (CT

SUBMITTER: Stene GB 

PROVIDER: S-EPMC6966581 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature