LSD1/KDM1A, a Gate-Keeper of Cancer Stemness and a Promising Therapeutic Target.

ABSTRACT: A new exciting area in cancer research is the study of cancer stem cells (CSCs) and the translational implications for putative epigenetic therapies targeted against them. Accumulating evidence of the effects of epigenetic modulating agents has revealed their dramatic consequences on cellular reprogramming and, particularly, reversing cancer stemness characteristics, such as self-renewal and chemoresistance. Lysine specific demethylase 1 (LSD1/KDM1A) plays a well-established role in the normal hematopoietic and neuronal stem cells. Overexpression of LSD1 has been documented in a variety of cancers, where the enzyme is, usually, associated with the more aggressive types of the disease. Interestingly, recent studies have implicated LSD1 in the regulation of the pool of CSCs in different leuk

SUBMITTER: Karakaidos P 

PROVIDER: S-EPMC6966601 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature