A Circulating miRNA Signature for Stratification of Breast Lesions among Women with Abnormal Screening Mammograms.

ABSTRACT: Although mammography is the gold standard for breast cancer screening, the high rates of false-positive mammograms remain a concern. Thus, there is an unmet clinical need for a non-invasive and reliable test to differentiate between malignant and benign breast lesions in order to avoid subjecting patients with abnormal mammograms to unnecessary follow-up diagnostic procedures. Serum samples from 116 malignant breast lesions and 64 benign breast lesions were comprehensively profiled for 2,083 microRNAs (miRNAs) using next-generation sequencing. Of the 180 samples profiled, three outliers were removed based on the principal component analysis (PCA), and the remaining samples were divided into training (n = 125) and test (n = 52) sets at a 70:30 ratio for further analysis. In the training set

SUBMITTER: Loke SY 

PROVIDER: S-EPMC6966622 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature