Paradoxical psoriasis induced by TNF-α blockade shows immunological features typical of the early phase of psoriasis development.

ABSTRACT: Immunomodulation with anti-TNF-α is highly effective in the treatment of various immune-mediated inflammatory diseases, including hidradenitis suppurativa (HS). However, this may be responsible for unexpected paradoxical psoriasiform reactions. The pathogenic mechanisms underlying the induction of these events are not clear, even though the involvement of innate immune responses driven by plasmacytoid dendritic cells (pDC) has been described. In addition, the genetic predisposition to psoriasis of patients could be determinant. In this study, we investigated the immunological and genetic profiles of three HS patients without psoriasis who developed paradoxical psoriasiform reactions following anti-TNF-α therapy with adalimumab. We found that paradoxical psoriasiform skin reactions show imm

SUBMITTER: Fania L 

PROVIDER: S-EPMC6966707 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature