∆Np63/p40 correlates with the location and phenotype of basal/mesenchymal cancer stem-like cells in human ER⁺ and HER2⁺ breast cancers.

ABSTRACT: ΔNp63, also known as p40, regulates stemness of normal mammary gland epithelium and provides stem cell characteristics in basal and HER2-driven murine breast cancer models. Whilst ΔNp63/p40 is a characteristic feature of normal basal cells and basal-type triple-negative breast cancer, some receptor-positive breast cancers express ΔNp63/p40 and its overexpression imparts cancer stem cell-like properties in ER⁺ cell lines. However, the incidence of ER⁺ and HER2⁺ tumours that express ΔNp63/p40 is unclear and the phenotype of ΔNp63/p40⁺ cells in these tumours remains uncertain. Using immunohistochemistry with p63 isoform-specific antibodies, we identified a ΔNp63/p40⁺ tumour cell subpopulation in 100 of 173 (58%) non-triple negative breast

SUBMITTER: Liu Y 

PROVIDER: S-EPMC6966710 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature