Cis-regulatory variation modulates susceptibility to enteric infection in the Drosophila genetic reference panel.

ABSTRACT:

Background

Resistance to enteric pathogens is a complex trait at the crossroads of multiple biological processes. We have previously shown in the Drosophila Genetic Reference Panel (DGRP) that resistance to infection is highly heritable, but our understanding of how the effects of genetic variants affect different molecular mechanisms to determine gut immunocompetence is still limited.

Results

To address this, we perform a systems genetics analysis of the gut transcriptomes from 38 DGRP lines that were orally infected with Pseudomonas entomophila. We identify a large number of condition-specific, expression quantitative trait loci (local-eQTLs) with infection-specific ones located in regions enriched for FOX transcription factor motifs. By assessing the allelic imbalance in

SUBMITTER: Frochaux MV 

PROVIDER: S-EPMC6966807 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature