Impact of omega-3 fatty acid oral therapy on healing of chronic venous leg ulcers in older adults: Study protocol for a randomized controlled single-center trial.

ABSTRACT:

Background

This trial addresses the global problem of chronic venous leg ulcers (CVLUs), wounds that cause significant infirmity for an estimated 9.7 million people annually, mainly older adults with comorbidities. Advanced therapies are needed because standard topical therapies are often ineffective or yield only short-term wound healing. Thus, we are testing a new oral therapy containing the bioactive elements of fish oil, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), for targeting and reducing the high numbers of activated polymorphonuclear leukocytes (PMN) in wound microenvironments that keep CVLUs "trapped" in a chronic inflammatory state.

Methods

This double-blind RCT will include 248 eligible adults ≥ 55 years of age with CVLUs receiving standard care at

SUBMITTER: McDaniel JC 

PROVIDER: S-EPMC6966808 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature