Dissecting the Extracellular Complexity of Neuromuscular Junction Organizers.

ABSTRACT: Synapse formation is a very elaborate process dependent upon accurate coordination of pre and post-synaptic specialization, requiring multiple steps and a variety of receptors and signaling molecules. Due to its relative structural simplicity and the ease in manipulation and observation, the neuromuscular synapse or neuromuscular junction (NMJ)-the connection between motor neurons and skeletal muscle-represents the archetype junction system for studying synapse formation and conservation. This junction is essential for survival, as it controls our ability to move and breath. NMJ formation requires coordinated interactions between motor neurons and muscle fibers, which ultimately result in the formation of a highly specialized post-synaptic architecture and a highly differentiated nerve ter

SUBMITTER: Guarino SR 

PROVIDER: S-EPMC6966886 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature