Association of the leptin receptor Q223R (rs1137101) polymorphism with obesity measures in Sri Lankans.

ABSTRACT:

Objective

The role of genetic factors in the development of obesity is largely unreported in Sri Lankans. The Q223R (rs1137101) single nucleotide polymorphism (SNP) of the leptin receptor (LEPR) gene has been associated with obesity measures in various ethnicities. We investigated the association of the Q223R polymorphism with obesity related anthropometric measures and biochemical parameters fasting blood glucose and lipid profile in a sample of 530 Sri Lankan adult subjects (age 18-70 years) representing both urban and rural areas of residence.

Results

The LEPR Q223R variant G allele frequency was 0.54. The polymorphism was associated with body mass index (p = 0.04) and waist circumference (p = 0.02) measures in overweight and obese (BMI ≥ 25 kgm^-2) subjects wit

SUBMITTER: Illangasekera YA 

PROVIDER: S-EPMC6966896 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature