Pharmacogene Variation in Thai Plasmodium vivax Relapse Patients Treated with a Combination of Primaquine and Chloroquine.

ABSTRACT:

Purpose

Pharmacogenes have an influence on biotransformation pathway and clinical outcome of primaquine and chloroquine which are often prescribed to treat Plasmodium vivax infection. Genetic variation may impact enzyme activity and/or transporter function and thereby contribute to relapse. The aim of the study was to assess allele, genotype frequencies and the association between pharmacogenes variation and primaquine response in Thai patients infected with Plasmodium vivax.

Patients and methods

Fifty-one patients were genotyped for 74 variants in 18 genes by Sequenom MassARRAY^® and Taqman^® SNP Real-Time PCR.

Results

SNP frequencies were not significantly different between relapse (n=4) and non-relapse (n=47) patients. However, the

SUBMITTER: Chamnanphon M 

PROVIDER: S-EPMC6966953 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature