Inflammation biomarker discovery in Parkinson's disease and atypical parkinsonisms.

ABSTRACT: BACKGROUND:Parkinson's disease (PD) and atypical parkinsonisms (APD) have overlapping symptoms challenging an early diagnosis. Diagnostic accuracy is important because PD and APD have different prognosis and response to treatment. We aimed to identify diagnostic inflammatory biomarkers of PD and APD in cerebrospinal fluid (CSF) using the multiplex proximity extension assay (PEA) technology and to study possible correlations of biomarkers with disease progression. METHODS:CSF from a longitudinal cohort study consisting of PD and APD patients (PD, n = 44; multiple system atrophy (MSA), n = 14; vascular parkinsonism (VaP), n = 9; and PD with VaP, n = 7) and controls (n = 25) were analyzed. RESULTS:Concentrations of CCL28 were elevated in PD compared to controls (p = 0.0001). Five other biomar

SUBMITTER: Santaella A 

PROVIDER: S-EPMC6967088 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature