Identification of a 13‑mRNA signature for predicting disease progression and prognosis in patients with bladder cancer.

ABSTRACT: There are no reliable criteria to assess risk of progression of non‑muscle invasive bladder cancer to muscle invasive bladder cancer. The aim of the present study was to identify potential markers based on gene expression profiling to improve predictive power of disease progression and prognosis in patients with bladder cancer. In the present study, we screened seventy‑three differentially expressed genes by analyzing bladder cancer samples with or without progression. Forty‑seven prognosis‑related genes were screened, 13 of which were identified to build a progression‑associated gene signature using the LASSO regression method. Based on this 13‑mRNA signature, patients were divided into high‑ and low‑risk groups, with different prognostic outcomes. The gene signature was an independent pr

SUBMITTER: Yin H 

PROVIDER: S-EPMC6967157 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature