Ontology highlight
ABSTRACT:
SUBMITTER: Yao Q
PROVIDER: S-EPMC6968488 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Yao Qing Q Lin Meng-Ting MT Lan Qing-Hua QH Huang Zhi-Wei ZW Zheng Ya-Wen YW Jiang Xue X Zhu Yin-Di YD Kou Longfa L Xu He-Lin HL Zhao Ying-Zheng YZ
Drug delivery 20201201 1
Didymin is a dietary flavonoid that first found in citrus fruits, and possesses antioxidant properties. Our preliminary experiments first discovered that didymin was able to sensitize the resistant cancer cells against chemotherapeutics and combat multidrug resistance. However, its poor aqueous solubility and resultant low bioavailability limit its potentials as an adjuvant phytochemical drug for chemotherapy. Thus, this study prepared the inclusion complex of didymin with β-cyclodextrin and 2-h ...[more]