New insights into human hair: SAXS, SEM, TEM and EDX for Alopecia Areata investigations.

ABSTRACT:

Background

Alopecia areata (AA) is a T-cell-mediated autoimmune disease and affects up to 2% of the population. There is a need for a more profound and rigorous understanding of the structure and composition of human hair affected by AA in order to manage this disease. The aim of this article is to understand the effects of AA on the structure and composition of human hair.

Methods

Several physico-chemical investigation methods, such as Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Energy-Dispersive X-ray Spectroscopy (EDX), and microbeam Small Angle X-ray Scattering (SAXS), were used to analyze human hair samples obtained from healthy donors and patients with AA.

Results

SEM revealed more severe hair surface defects for the white regrown

SUBMITTER: Coroaba A 

PROVIDER: S-EPMC6968496 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature