Nuclear magnetic resonance (NMR)-based metabolome profile evaluation in dairy cows with and without displaced abomasum.

ABSTRACT: Background: Displaced abomasum (DA) is a condition of dairy cows that severely impacts animal welfare and causes huge economic losses.Objective: To assess the metabolic status of the disease using metabolomics in serum, urine and liver samples aimed at both water soluble and lipid soluble fractions.Methods: Fifty Holstein multiparous cows with DA (42 left, 8 right) and 20 clinically healthy Holstein multiparous cows were used. Left DA was associated with concomitant ketosis in 19 animals and right in two. NMR-based metabolomics approach and hematological and biochemical analyses were performed. Statistical analysis was carried out on ¹H-NMR data after they have been normalized using PQN method.Results: Contrary to generated PCA score plots the OPLS-su

SUBMITTER: Basoglu A 

PROVIDER: S-EPMC6968509 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature