[12]aneN₃-based multifunctional compounds as fluorescent probes and nucleic acids delivering agents.

ABSTRACT: A series of multifunctional compounds (MFCs) 1a-1e based on 1,8-naphthalimide and [12]aneN₃ building blocks were designed and synthesized. They were used as not only fluorescent probes for recognition of Cu²⁺ ions but also as non-viral gene vectors for DNA and RNA delivery. Furthermore, their complexes with Cu²⁺ (1-Cu) could also selectively stain lysosome in HeLa cells. In order to achieve high performance multifunctional materials, structure-performance relationship of MFCs 1a-1e was studied. It was found that MFCs 1a-1e exhibited highly selective fluorescence turn-off for Cu²⁺, without interference by other metal ions in aqueous solution. The fluorescence emission of 1a-1e was quenched by a fact

SUBMITTER: Gao YG 

PROVIDER: S-EPMC6968532 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature