Transcriptome Analysis Reveals Key Genes and Pathways Associated with Metastasis in Breast Cancer.

ABSTRACT:

Background

Metastasis is the major cause of death in breast cancer patients. Although the strategies targeting metastasis have promoted survival, the underlying mechanisms still remain unclear. In this study, we used microarray data of primary breast tumor, tumor derived from bone and liver, and skin metastatic tissue, to identify the key genes and pathways that are involved in metastasis in breast cancer.

Methods

We first calculated the differentially expressed genes (DEGs) between three metastatic tissues and primary tumor tissue, and then used it to perform Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Further, we analyzed the correlation of genes enriched in GO terms and KEGG pathways with survival of breast cancer pat

SUBMITTER: Li W 

PROVIDER: S-EPMC6968804 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature