Integrated targeted serum metabolomic profile and its association with gender, age, disease severity, and pattern identification in acne.

ABSTRACT: BACKGROUND:Westernized diet and nutritional metabolism are important in acne pathogenesis, especially in adult patients. However, clinical and basic data are lacking. Pattern identification (PI) is a tool that results in a diagnostic conclusion based on a cluster of concurrent symptoms and signs in traditional medicine. Acne can be classified by PI. However, whether the metabolomic profile differs according to the PI of acne is unknown. Metabolomic data would help clarify the pathogenesis of acne. METHODS:We conducted a cross-sectional study involving 40 healthy controls and 60 subjects with acne. We evaluated androgens, serum lipids, essential amino acids, nonessential amino acids, other amino acids, and pro-inflammatory cytokines of all subjects and compared the metabolomic profiles betw

SUBMITTER: Kim MH 

PROVIDER: S-EPMC6968861 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature