Accelerated development of cocaine-associated dopamine transients and cocaine use vulnerability following traumatic stress.

ABSTRACT: Post-traumatic stress disorder and cocaine use disorder are highly co-morbid psychiatric conditions. The onset of post-traumatic stress disorder generally occurs prior to the development of cocaine use disorder, and thus it appears that the development of post-traumatic stress disorder drives cocaine use vulnerability. We recently characterized a rat model of post-traumatic stress disorder with segregation of rats as susceptible and resilient based on anxiety-like behavior in the elevated plus maze and context avoidance. We paired this model with in vivo fast scan cyclic voltammetry in freely moving rats to test for differences in dopamine signaling in the nucleus accumbens core at baseline, in response to a single dose of cocaine, and in response to cocaine-paired cues. Further, we examin

SUBMITTER: Brodnik ZD 

PROVIDER: S-EPMC6969179 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature