Increased variability of stimulus-driven cortical responses is associated with genetic variability in children with and without dyslexia.

ABSTRACT: Individuals with dyslexia exhibit increased brainstem variability in response to sound. It is unknown as to whether increased variability extends to neocortical regions associated with audition and reading, extends to visual stimuli, and whether increased variability characterizes all children with dyslexia or, instead, a specific subset of children. We evaluated the consistency of stimulus-evoked neural responses in children with (N = 20) or without dyslexia (N = 12) as measured by magnetoencephalography (MEG). Approximately half of the children with dyslexia had significantly higher levels of variability in cortical responses to both auditory and visual stimuli in multiple nodes of the reading network. There was a significant and positive relationship between the number of risk alleles a

SUBMITTER: Centanni TM 

PROVIDER: S-EPMC6969288 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature