Functional interaction between plasma phospholipid fatty acids and insulin resistance in leucocyte telomere length maintenance.

ABSTRACT: BACKGROUND:Previous evidence suggests that plasma phospholipid fatty acids (PPFAs) and HOMA insulin resistance (HOMA-IR) are independently related to leukocyte telomere length (LTL). However, there is limited evidence of regarding the effect of their interaction on relative LTL (RLTL). Therefore, here, we aimed to determine the effect of the interaction between PPFAs and HOMA-IR on RLTL. METHODS:We conducted a cross-sectional study, involving a total of 1246 subjects aged 25-74 years. PPFAs and RLTL were measured, and HOMA-IR was calculated. The effect of the interaction between PPFAs and HOMA-IR on RLTL was assessed by univariate analysis, adjusting for potential confounders. RESULTS:In age-adjusted analyses, multivariate linear regression revealed a significant association of the levels

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC6969400 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature