Variable functional connectivity architecture of the preterm human brain: Impact of developmental cortical expansion and maturation.

ABSTRACT: Functional connectivity (FC) is known to be individually unique and to reflect cognitive variability. Although FC can serve as a valuable correlate and potential predictor of (patho-) physiological nervous function in high-risk constellations, such as preterm birth, templates for individualized FC analysis are lacking, and knowledge about the capacity of the premature brain to develop FC variability is limited. In a cohort of prospectively recruited, preterm-born infants undergoing magnetic resonance imaging close to term-equivalent age, we show that the overall pattern could be reliably detected with a broad range of interindividual FC variability in regions of higher-order cognitive functions (e.g., association cortices) and less interindividual variability in unimodal regions (e.g., vis

SUBMITTER: Stoecklein S 

PROVIDER: S-EPMC6969522 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature