Genetic architecture study of rheumatoid arthritis and juvenile idiopathic arthritis.

ABSTRACT:

Background

Rheumatoid arthritis and juvenile idiopathic arthritis are two types of autoimmune diseases with inflammation at the joints, occurring to adults and children respectively. There are phenotypic overlaps between these two types of diseases, despite the age difference in patient groups.

Methods

To systematically compare the genetic architecture of them, we conducted analyses at gene and pathway levels and constructed protein-protein-interaction network based on summary statistics of genome-wide association studies of these two diseases. We examined their difference and similarity at each level.

Results

We observed extensive overlap in significant SNPs and genes at the human leukocyte antigen region. In addition, several SNPs in other regions of the human genom

SUBMITTER: Jia J 

PROVIDER: S-EPMC6969553 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature