Metabolite profile comparisons between ascending and descending colon tissue in healthy adults.

ABSTRACT: BACKGROUND:Obesity is a risk factor for colorectal cancer, yet metabolic distinctions between healthy right and left colon tissue, before cancer is diagnosed, remains largely unknown. This study compared right-ascending and left-descending colon tissue metabolomes to identify differences from the stool metabolome in normal weight, overweight, and obese adults. AIM:To examine right and left colon tissue metabolites according to body mass index that may serve as mechanistic targets for interventions and biomarkers for colon cancer risk. METHODS:Global, non-targeted metabolomics was applied to assess right-ascending and left-descending colon tissue collected from healthy adults undergoing screening colonoscopies to test the hypothesis that BMI differentially impacts colon tissue metabolite pr

SUBMITTER: Baxter BA 

PROVIDER: S-EPMC6969882 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature