Nucleotide excision repair pathway gene polymorphisms are associated with risk and prognosis of colorectal cancer.

ABSTRACT:

Background

Single nucleotide polymorphisms (SNPs) are universally present in nucleotide excision repair (NER) pathway genes, which could make impacts on colorectal carcinogenesis and prognosis.

Aim

To explore the association of all tagSNPs in NER pathway genes with colorectal cancer (CRC) risk and prognosis in a northern Chinese population by a two-stage case-control design composed of a discovery and validation stage.

Methods

Genotyping for NER SNPs was performed using kompetitive allele specific PCR. In the discovery stage, 39 tagSNPs in eight genes were genotyped in 368 subjects, including 184 CRC cases and 184 individual-matched controls. In the validation stage, 13 SNPs in six genes were analyzed in a total of 1712 subjects, including 854 CRC cases and 858 CRC-fr

SUBMITTER: Li YK 

PROVIDER: S-EPMC6969885 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature