PET imaging of mGluR5 in Alzheimer's disease.

ABSTRACT:

Background

Metabotropic glutamate subtype 5 receptors (mGluR5) modulate synaptic transmission and may constitute an important therapeutic target in Alzheimer's disease (AD) by mediating the synaptotoxic action of amyloid-β oligomers. We utilized the positron emission tomography (PET) radioligand [¹⁸F]FPEB to investigate mGluR5 binding in early AD.

Methods

Sixteen individuals with amnestic mild cognitive impairment (MCI) due to AD or mild AD dementia who were positive for brain amyloid were compared to 15 cognitively normal (CN) participants who were negative for brain amyloid. Diagnostic groups were well balanced for age, sex, and education. Dynamic PET scans were acquired for 60 min, starting at 60 min after the initial administration of up to 185 MBq of [¹⁸

SUBMITTER: Mecca AP 

PROVIDER: S-EPMC6969979 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature