The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis.

ABSTRACT: Cilia and flagella are critical organelles with conserved internal structures and diverse developmental and physiological processes according to cell type. Although the core components of structures are shared with thousands of associated proteins involved in cilia or flagella formation, we hypothesized that some unknown proteins, such as outer dense fiber 2 (Odf2/Cenexin) perform distinct functions in these organelles. In the present study, we identified several uncharacterized proteins through mass spectrometry interactome analysis of Odf2/Cenexin proteins. We further examined the expression patterns and functions of a protein named cilia and flagella associated protein 58 (Cfap58) in cultured astrocytes and sperm flagella. The results of a combination of biochemical analyses and drug ad

SUBMITTER: Li ZZ 

PROVIDER: S-EPMC6970087 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature