Mortality from HIV-associated meningitis in sub-Saharan Africa: a systematic review and meta-analysis.

ABSTRACT:

Introduction

HIV-associated cryptococcal, TB and pneumococcal meningitis are the leading causes of adult meningitis in sub-Saharan Africa (SSA). We performed a systematic review and meta-analysis with the primary aim of estimating mortality from major causes of adult meningitis in routine care settings, and to contrast this with outcomes from clinical trial settings.

Methods

We searched PubMed, EMBASE and the Cochrane Library for published clinical trials (defined as randomized-controlled trials (RCTs) or investigator-managed prospective cohorts) and observational studies that evaluated outcomes of adult meningitis in SSA from 1 January 1990 through 15 September 2019. We performed random effects modelling to estimate pooled mortality, both in clinical trial and routine care

SUBMITTER: Tenforde MW 

PROVIDER: S-EPMC6970088 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature