The effect of time since measles vaccination and age at first dose on measles vaccine effectiveness - A systematic review.

ABSTRACT:

Background

In settings where measles has been eliminated, vaccine-derived immunity may in theory wane more rapidly due to a lack of immune boosting by circulating measles virus. We aimed to assess whether measles vaccine effectiveness (VE) waned over time, and if so, whether differentially in measles-eliminated and measles-endemic settings.

Methods

We performed a systematic literature review of studies that reported VE and time since vaccination with measles-containing vaccine (MCV). We extracted information on case definition (clinical symptoms and/or laboratory diagnosis), method of vaccination status ascertainment (medical record or vaccine registry), as well as any biases which may have arisen from cold chain issues and a lack of an age at first dose of MCV. We then used

SUBMITTER: Hughes SL 

PROVIDER: S-EPMC6970218 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature