Increased minimum alveolar concentration-awake of Sevoflurane in women of breast surgery with sleep disorders.

ABSTRACT:

Background

Sleep disorders are commonly encountered in clinic. Evidences showed that sleep deprivation may modulate the effectiveness of general anesthetics in rats. However, this phenomenon has not been explored in humans. The study aimed to investigate whether the hypnotic potency of sevoflurane in patients with sleep disorders differ from patients with normal sleep habits.

Methods

We recruited 44 patients scheduled for elective breast surgery and eventually analyzed 38 patients, including 19 subjects with normal sleep habits and 19 subjects with sleep disorders. According to the Dixon 'up-and-down' design, patients received sevoflurane at preselected concentrations starting at 1.0 vol%. After a steady-state period, a verbal command for testing awakening was performed. Bas

SUBMITTER: Cao Y 

PROVIDER: S-EPMC6970294 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature