EQTLMAPT: Fast and Accurate eQTL Mediation Analysis With Efficient Permutation Testing Approaches.

ABSTRACT: Expression quantitative trait locus (eQTL) analyses are critical in understanding the complex functional regulatory natures of genetic variation and have been widely used in the interpretation of disease-associated variants identified by genome-wide association studies (GWAS). Emerging evidence has shown that trans-eQTL effects on remote gene expression could be mediated by local transcripts, which is known as the mediation effects. To discover the genome-wide eQTL mediation effects combing genomic and transcriptomic profiles, it is necessary to develop novel computational methods to rapidly scan large number of candidate associations while controlling for multiple testing appropriately. Here, we present eQTLMAPT, an R package aiming to perform eQTL mediation analysis with implement

SUBMITTER: Wang T 

PROVIDER: S-EPMC6970436 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature