Molecular Biomarkers of Sessile Serrated Adenoma/Polyps.

ABSTRACT:

Objectives

Sessile serrated adenoma/polyps (SSA/Ps) contribute up to 30% of all colon cancers. There is considerable histological overlap between SSA/Ps and hyperplastic polyps. Inadequate consensus exists among pathologists, and no molecular biomarkers exist to differentiate these lesions with high accuracy. Lack of reliable diagnosis adversely affects clinical care. We previously defined a novel 7-gene panel by RNA sequencing that differentiates SSA/Ps from hyperplastic polyps. Here, we use the 7-gene panel as a molecular approach to differentiate SSA/Ps and HPs with higher sensitivity and specificity in a large sample set from a tertiary health care center.

Methods

Reverse transcription quantitative polymerase chain reaction of the 7-gene panel was performed on 223 formal

SUBMITTER: Kanth P 

PROVIDER: S-EPMC6970553 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature